A focused series of substituted 4H-1,2,6-thiadiazin-4-ones was designed and synthesized to probe the anti-cancer properties of this scaffold.Insights from previous kinase inhibitor programs were used to carefully select several Plastic Translucent Cups different substitution patterns.Compounds were tested on bladder, prostate, pancreatic, breast, c

The paper explores the representation of ageing white men in 21st-century European art cinema in the socio-cultural context of the series of crises that European societies had to face in the first decades of the new millennium.In Bath Bombs Europe ageing is a growing concern, which already influences economic productivity and further endangers the

A small-scale (up to 5 kWe) biogas-solid oxide fuel cell (SOFC) energy system is an envisioned system, which can be used to meet both electrical and thermal energy demand of off-grid settlements.SOFC systems are reported to be more efficient than alternatives like internal combustion engines (ICE).In addition to energy recovery, implementation of b

Abstract Hypoxia promotes aggressive tumor phenotypes and mediates the recruitment of suppressive T cells in invasive breast carcinomas.We investigated Hats the role of hypoxia in relation to T-cell regulation in ductal carcinoma in situ (DCIS).We designed a deep learning system tailored for the tissue architecture complexity of DCIS, and compared

Dentists and medical personnel strive to provide patients with prompt medical services.In the past, Dental Panoramic Radiograph (DPR) was often used to diagnose and understand the dental condition of patients.In recent years, many machine learning and deep learning methods have been applied to medical image recognition problems.Moreover, when combi